GNOM: Healthcare Dashboard For January (NASDAQ:GNOM)

This monthly article series shows a dashboard with aggregate industry metrics in healthcare. It may also serve as a top-down analysis of sector ETFs like the iShares U.S. Healthcare ETF (IYH) and the Health Care Select Sector SPDR ETF (XLV), whose largest holdings are used to calculate these metrics. This month’s article will focus on a lesser-known fund: the Global X Genomics & Biotechnology ETF (NASDAQ:GNOM).

Shortcut

The next two paragraphs in italic describe the dashboard methodology. They are necessary for new readers to understand the metrics. If you are used to this series or if you are short of time, you can skip them and go to the charts.

Base Metrics

I calculate the median value of five fundamental ratios for each industry: Earnings Yield (“EY”), Sales Yield (“SY”), Free Cash Flow Yield (“FY”), Return on Equity (“ROE”), Gross Margin (“GM”). The reference universe includes large companies in the U.S. stock market. The five base metrics are calculated on trailing 12 months. For all of them, higher is better. EY, SY and FY are medians of the inverse of Price/Earnings, Price/Sales and Price/Free Cash Flow. They are better for statistical studies than price-to-something ratios, which are unusable or non available when the “something” is close to zero or negative (for example, companies with negative earnings). I also look at two momentum metrics for each group: the median monthly return (RetM) and the median annual return (RetY).

I prefer medians to averages because a median splits a set in a good half and a bad half. A capital-weighted average is skewed by extreme values and the largest companies. My metrics are designed for stock-picking rather than index investing.

Value and Quality Scores

I calculate historical baselines for all metrics. They are noted respectively EYh, SYh, FYh, ROEh, GMh, and they are calculated as the averages on a look-back period of 11 years. For example, the value of EYh for healthcare providers in the table below is the 11-year average of the median Earnings Yield in this industry.

The Value Score (“VS”) is defined as the average difference in % between the three valuation ratios (EY, SY, FY) and their baselines (EYh, SYh, FYh). The same way, the Quality Score (“QS”) is the average difference between the two quality ratios (ROE, GM) and their baselines (ROEh, GMh).

The scores are in percentage points. VS may be interpreted as the percentage of undervaluation or overvaluation relative to the baseline (positive is good, negative is bad). This interpretation must be taken with caution: the baseline is an arbitrary reference, not a supposed fair value. The formula assumes that the three valuation metrics are of equal importance.

Current data

The next table shows the metrics and scores as of last week’s closing. Columns stand for all the data named and defined above.

	VS	QS	EY	SY	FY	ROE	GM	EYh	SYh	FYh	ROEh	GMh	RetM	RetY
HC Equipment	-31.70	-8.31	0.0245	0.2072	0.0176	10.92	65.90	0.0327	0.2757	0.0321	13.75	63.37	1.33%	-10.99%
HC Providers	6.41	-3.31	0.0528	1.4614	0.0730	17.69	20.02	0.0525	1.4296	0.0627	15.92	24.35	-0.83%	3.50%
Pharma/Biotech	15.40	24.59	0.0487	0.2100	0.0442	32.30	79.04	0.0372	0.2451	0.0341	21.36	80.69	-1.71%	24.25%
Life Science Tools	-27.39	7.15	0.0272	0.1707	0.0207	17.16	58.84	0.0298	0.2856	0.0310	15.96	55.10	2.84%	-8.81%

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Value and Quality chart

The next chart plots the Value and Quality Scores by industry (higher is better).

Evolution since last month

The value score has improved in pharmaceuticals/biotechnology, healthcare providers, and deteriorated in life science tools.

Momentum

The next chart plots momentum data.

Interpretation

Pharma/biotech is the most attractive healthcare subsector: it undervalued by about 15% relative to 11-year averages, and the quality score is excellent. Healthcare providers are undervalued by about 6% regarding the same metrics, and quality is very close below the baseline. Life science tools and healthcare equipment are overvalued by about 27% and 32%, respectively. Life science tools have a better quality score.

Fast facts on GNOM

Genomics is a very promising field in the pharma/biotech industry. The Global X Genomics & Biotechnology ETF (GNOM) was launched on 04/05/2019 to provide exposure to innovative companies in genomics and genetic medicine. Its total expense ratio is similar to the iShares Nasdaq Biotechnology ETF (IBB): 0.50% vs. 0.44%. Both are significantly above XLV (0.10%).

As described by Global X ETFs, companies are screened based on revenue exposure to one of the following business operations: gene editing, genomic sequencing, development and testing of genetic medicine/therapies, computational genomics and genetic diagnostics. Companies that derive at least 50% of revenue from these operations are eligible for the index. Other companies that are classified as “Biotechnology” by FactSet are further reviewed and analyzed based on R&D expenditures, product pipeline, and operating business segments. Those companies with exposure to the genomics-related business activities are also eligible for the index.

Then, eligible companies of both sets described above are ranked together by a score based on a natural language processing algorithm that evaluates publicly available information such as financial websites, search engines, and company publications. The 40 highest ranking companies constitute the final index.

GNOM holds 40 stocks. The portfolio is quite concentrated: the aggregate weight of the top 10 holdings is 45.3% (list below).

Ticker	Name	Weight%	EPS growth %TTM	P/E TTM	P/E fwd	Yield%
TXG	10X Genomics, Inc.	5.93	65.14	N/A	N/A	0
1548 HK	Genscript Biotech Corp	4.98
BMRN	BioMarin Pharmaceutical, Inc.	4.63	1273.60	268.50	168.89	0
ALNY	Alnylam Pharmaceuticals, Inc.	4.42	-37.02	N/A	N/A	0
SRPT	Sarepta Therapeutics, Inc.	4.34	-33.97	N/A	N/A	0
QGEN	Qiagen NV	4.3	-21.38	24.98	21.84	0
A	Agilent Technologies, Inc.	4.29	5.87	37.18	27.43	0.58
ARWR	Arrowhead Pharmaceuticals, Inc.	4.28	-23.88	N/A	N/A	0
TECH	Bio-Techne Corp.	4.08	65.08	45.26	38.50	0.40
RARE	Ultragenyx Pharmaceutical, Inc.	4.05	-84.20	N/A	N/A	0

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Since 06/11/2019, GNOM has underperformed its competitors iShares Genomics Immunology and Healthcare ETF (IDNA) and Invesco Dynamic Biotechnology & Genome ETF (PBE). It also lags the sector benchmark XLV, and the industry benchmark IBB (see next chart). Price history may be too short to assess the strategy on past performance, but for an investor looking for a genomics ETF, PBE shows a better return with a lower volatility. Moreover, as a software engineer with a certification in machine learning, I think the fund’s strategy makes a questionable use of NLP: public information may be biased by marketing content and company self-descriptions.

Dashboard List

I use the first table to calculate value and quality scores. It may also be used in a stock-picking process to check how companies stand among their peers. For example, the EY column tells us that a large pharma/biotech company with an Earnings Yield above 0.0487 (or price/earnings below 20.53) is in the better half of the industry regarding this metric. A Dashboard List is sent every month to Quantitative Risk & Value subscribers with the most profitable companies standing in the better half among their peers regarding the three valuation metrics at the same time. The list below was sent to subscribers several weeks ago based on data available at this time.

VIR	Vir Biotechnology, Inc.
DVAX	Dynavax Technologies Corp.
IRWD	Ironwood Pharmaceuticals, Inc.
AMN	AMN Healthcare Services, Inc.
DVA	DaVita, Inc.
INVA	Innoviva, Inc.
PFE	Pfizer Inc.
MOH	Molina Healthcare, Inc.
ZYXI	Zynex, Inc.
ORGO	Organogenesis Holdings, Inc.

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It is a rotational list with a statistical bias toward excess returns on the long-term, not the result of an analysis of each stock.